Recombinant Human SIVA1, apoptosis-inducing factor, His-tagged

• Cat.No.: SIVA1-277H
• Product Overview: SIVA1, 1-175aa, Human, His tag, E.coli

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-175 a.a.
• Description: Apoptosis regulatory protein Siva isoform 1, also known as SIVA1, is a death domain-containing proapoptotic protein identified as an intracellular ligand of CD27 and of the glucocorticoid-induced TNFR family-related gene, which are two members of the TNFR family expressed on lymphoid cells. SIVA1 expression is up-regulated in multiple pathological processes, little is known about the signaling pathway underlying the Siva-induced apoptosis. Recombinant human SIVA1 protein, fused to His-tag at N-terminus, was expressed in E.coli. (denatured)
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea
• Molecular Mass: 21.1 kDa (198aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMPKRSCP FADVAPLQLK VRVSQRELSR GVCAERYSQE VFEKTKRLLF LGAQAYLDHV WDEGCAVVHL PESPKPGPTG APRAARGQML IGPDGRLIRS LGQASEADPS GVASIACSSC VRAVDGKAVC GQCERALCGQ CVRTCWGCGS VACTLCGLVD CSDMYEKVLC TSCAMFET
• Purity: >85% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: SIVA1 SIVA1, apoptosis-inducing factor [ Homo sapiens ]
• Official Symbol: SIVA1
• Synonyms: SIVA1; SIVA1, apoptosis-inducing factor; apoptosis regulatory protein Siva; CD27BP; SIVA; Siva 1; Siva 2; CD27-binding (Siva) protein; Siva-1; Siva-2
• Gene ID: 10572
• mRNA Refseq: NM_006427
• Protein Refseq: NP_006418
• MIM: 605567
• UniProt ID: O15304
• Chromosome Location: 14q32.33
• Function: CD27 receptor binding; cysteine-type endopeptidase activator activity involved in apoptotic process; metal ion binding; protein binding; viral receptor activity; zinc ion binding