SIVA1
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Official Full Name
SIVA1, apoptosis-inducing factor -
Overview
This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. -
Synonyms
SIVA1;SIVA1, apoptosis-inducing factor;apoptosis regulatory protein Siva;CD27BP;SIVA;Siva 1;Siva 2;CD27 binding (Siva) protein;CD27-binding (Siva) protein;Siva-1;Siva-2
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cells
- E.Coli/Yeast
- HEK293
- Yeast
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
- SUMO
Involved Pathway
SIVA1 involved in several pathways and played different roles in them. We selected most pathways SIVA1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SIVA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SIVA1 has several biochemical functions, for example, CD27 receptor binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIVA1 itself. We selected most functions SIVA1 had, and list some proteins which have the same functions with SIVA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | NRBP1,RBBP7,CLEC18A,FCER1G,LETM1,EIF3I,CNTNAP2,MAP2K4,IL7,SVIP |
| virus receptor activity | TNFRSF4,CR2,ACE2,PVRL1,SELPLG,AXL,CD209,GPR172B,HAVCR1,ITGB5 |
| zinc ion binding | ADAM28,MT3,PDLIM5B,LIMD1,Alb,TNFAIP3,TRIM23,ADAMTSL3,VPS11,LMO4A |
| metal ion binding | ABLIM1B,ZNF597,ZFP629,COX5B,ALKBH6,MYLK,ZNF471,EBF2,KCND2,PRICKLE2B |
Interacting Protein
SIVA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIVA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIVA1.
CD27;E7;PXMP2;BCL2;BCL2L1;BCL2L1;PCNA;NGFRAP1;erpA;GRINL1A
Resources
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References
- Sebastian, A; Iqbal, SA; et al. Electrical Stimulation Enhances Epidermal Proliferation in Human Cutaneous Wounds by Modulating p53-SIVA1 Interaction. JOURNAL OF INVESTIGATIVE DERMATOLOGY 135:1166-1174(2015).
- Machado-Neto, JA; Lazarini, M; et al. ANKHD1 silencing inhibits Stathmin 1 activity, cell proliferation and migration of leukemia cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1853:583-593(2015).
