Recombinant Human SIRT5

Cat.No. : SIRT5-31167TH
Product Overview : Recombinant full length Human SIRT5 protein with N-terminal proprietary tag, 60 kDa.
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Species : Human
Source : E.coli
Tag : Non
Description : This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants.
Tissue specificity : Widely expressed.
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 20% Glycerol, 0.05% Tween 20, 25mM Tris HCl, 100mM Sodium chloride, pH 8
Storage : Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the sirtuin family.Contains 1 deacetylase sirtuin-type domain.
Full Length : Full L.
Gene Name SIRT5 sirtuin 5 [ Homo sapiens ]
Official Symbol SIRT5
Synonyms SIRT5; sirtuin 5; sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 5; NAD-dependent deacetylase sirtuin-5;
Gene ID 23408
mRNA Refseq NM_001193267
Protein Refseq NP_001180196
MIM 604483
Uniprot ID Q9NXA8
Chromosome Location 6p23
Pathway Signaling events mediated by HDAC Class I, organism-specific biosystem;
Function NOT NAD+ ADP-ribosyltransferase activity; NAD+ binding; hydrolase activity; metal ion binding; zinc ion binding;

Not For Human Consumption!

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