Recombinant Human SIRT5
Cat.No. : | SIRT5-31167TH |
Product Overview : | Recombinant full length Human SIRT5 protein with N-terminal proprietary tag, 60 kDa. |
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Species : | Human |
Source : | E.coli |
Tag : | Non |
Description : | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. |
Tissue specificity : | Widely expressed. |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 20% Glycerol, 0.05% Tween 20, 25mM Tris HCl, 100mM Sodium chloride, pH 8 |
Storage : | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Belongs to the sirtuin family.Contains 1 deacetylase sirtuin-type domain. |
Full Length : | Full L. |
Gene Name | SIRT5 sirtuin 5 [ Homo sapiens ] |
Official Symbol | SIRT5 |
Synonyms | SIRT5; sirtuin 5; sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 5; NAD-dependent deacetylase sirtuin-5; |
Gene ID | 23408 |
mRNA Refseq | NM_001193267 |
Protein Refseq | NP_001180196 |
MIM | 604483 |
Uniprot ID | Q9NXA8 |
Chromosome Location | 6p23 |
Pathway | Signaling events mediated by HDAC Class I, organism-specific biosystem; |
Function | NOT NAD+ ADP-ribosyltransferase activity; NAD+ binding; hydrolase activity; metal ion binding; zinc ion binding; |
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Not For Human Consumption!
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