Recombinant Human SIRT5

Cat.No. : SIRT5-342H
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Species : Human
Source : E.coli
Tag : Non
Description : Sirtuins are pylogenetically conserved from bacteria to humans and regulate cell functions beyond silencing. The proteins show a relevance to cancer, obesity, muscle differentiation, inflammation and neuro-degeneration. In addition, Sirtuin activity may extend the lifespan of several organisms. Human Sirtuin 5 (Sirt5) is a mitochondrial member of Class III of the protein deacetylases family (historically called histone deacetylases family). Class III deacetylases utilize NAD+ as cosubstrate and act either as deacetylases or as ADP-ribosyltransferases. MW=29.9kDa (275 amino acids).
Form : Purified recombinant protein in 20mM Tris-HCl pH7.8, 150mM NaCl and 2mM DTT.
Purity : >95% by SDS-PAGE.
Usage : For in vitro use only.
Storage : Quality guaranteed for 12 months store at -80℃. Avoid freeze / thaw cycles.
Gene Name SIRT5 sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) [ Homo sapiens ]
Synonyms SIRT5; sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae); SIR2L5; FLJ36950; sirtuin 5; sir2-like 5; sirtuin type 5; silent mating type information regulation 2, S.cerevisiae, homolog 5; EC 3.5.1.-; OTTHUMP00000016054; OTTHUMP00000016055; SIR2-like protein 5; sirtuin (silent mating type information regulation; S.cerevisiae, homolog) 5
Gene ID 23408
mRNA Refseq NM_012241
Protein Refseq NP_036373
MIM 604483
UniProt ID Q9NXA8
Chromosome Location 6p23
Function NAD binding; NAD+ ADP-ribosyltransferase activity; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; metal ion binding; zinc ion binding

Not For Human Consumption!

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