Recombinant Human SIRT4, GST-tagged

• Cat.No.: SIRT4-465H
• Product Overview: Recombinant Human SIRT4 (amino acids 25-314) was expressed in anE.coliexpression system with N-terminal GST tag. MW=59 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 25-314 a.a.
• Description: Sirtuin 4, also known as SIRT4 is a protein which in humans is encoded by the SIRT4 gene. This gene encodes a member of the sirtuin family of proteins which are homologs of the Sir2 gene in budding yeast. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been fully determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA.
• Formulated In: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 20% glycerol.
• Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Purity: > 90%.
• Stability: >6 months at -80°C.

Gene Information

• Gene Name: SIRT4 sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) [ Homo sapiens ]
• Synonyms: sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae); SIR2L4; MGC57437; MGC130046; MGC130047; SIRT4; sirtuin 4; sir2-like 4; sirtuin type 4; EC 3.5.1.-; SIR2-like protein 4; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 4
• Gene ID: 23409
• mRNA Refseq: NM_012240
• Protein Refseq: NP_036372
• MIM: 604482
• UniProt ID: Q9Y6E7
• Chromosome Location: 12q
• Function: NAD binding; NAD+ ADP-ribosyltransferase activity; NAD-dependent protein deacetylase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; metal ion binding; protein binding; transferase activity; zinc ion binding