SIRT4

  • Official Full Name

    sirtuin 4

  • Overview

    This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.

  • Synonyms

    SIRT4;sirtuin 4;sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 4;NAD-dependent ADP-ribosyltransferase sirtuin-4;SIR2L4;sir2-like 4;sirt

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • Mammalian Cell
  • HEK293
  • His
  • Non
  • GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
SIRT4-2682H Recombinant Full Length Human SIRT4, His-tagged E.coli Human His Full L. 1-314aa
Sirt4-1377M Recombinant Mouse Sirt4 protein, His-tagged E.coli Mouse His Ser26~Pro333
Sirt4-1378R Recombinant Rat Sirt4 protein, His-tagged E.coli Rat His Ala60~Val255
SIRT4-1513Z Recombinant Zebrafish SIRT4 Mammalian Cell Zebrafish His
SIRT4-15154M Recombinant Mouse SIRT4 Protein Mammalian Cell Mouse His
SIRT4-30844TH Recombinant Human SIRT4 E.coli Human Non 25-314 a.a.
SIRT4-30846TH Recombinant Human SIRT4 E.coli Human Non 314 amino acids
SIRT4-465H Recombinant Human SIRT4, GST-tagged E.coli Human GST 25-314 a.a.
SIRT4-4879H Recombinant Full Length Human Sirtuin 4, GST-tagged E.coli Human GST Full L.
SIRT4-1831HCL Recombinant Human SIRT4 293 Cell Lysate HEK293 Human Non
SIRT4-024H Recombinant Full Length Human SIRT4 Protein, GST-tagged E.coli Human GST Full L. 1-314
SIRT4-111H Recombinant Human SIRT4 Protein, GST-tagged E.coli Human GST 1-314
SIRT4-25H Recombinant Human SIRT4 protein, His-tagged E.coli Human His Ser28-Cys314
SIRT4-3477H Recombinant Human SIRT4 Protein (Ser28-Cys314), His tagged E.coli Human His Ser28-Cys314
SIRT4-8182M Recombinant Mouse SIRT4 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
SIRT4-8182M-B Recombinant Mouse SIRT4 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    SIRT4 involved in several pathways and played different roles in them. We selected most pathways SIRT4 participated on our site, such as Signaling events mediated by HDAC Class I, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIRT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling events mediated by HDAC Class I TFCP2,GATA1,FKBP3,PRMT5,GATA2,WDR77,MXD1,SIRT7,SIRT2,SIRT5

    Protein Function

    SIRT4 has several biochemical functions, for example, NAD+ ADP-ribosyltransferase activity,NAD+ binding,NOT NAD-dependent protein deacetylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIRT4 itself. We selected most functions SIRT4 had, and list some proteins which have the same functions with SIRT4. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding ABO,PLCD3A,TRIM35-7,ZFP1,KDM7AB,GNAI3,GNAT1,PDE4D,ZNF511,ZNF526
    NAD+ binding SIRT1,GLUD1,SIRT6,ALDH1A3,UXS1,HADH,SIRT7,SIRT3,SIRT2,HPGD
    protein binding SMAD5,SH2D3A,SGCA,JUB,FRG1,KIF6,HBA1,NUFIP2,IFT27,BRAP
    biotinidase activity BTD
    NAD+ ADP-ribosyltransferase activity GIG2O,PARP8,PARP12,ART3,PARP14,TIPARP,GIG2G,PARP12A,ZC3HAV1,GIG2J

    Interacting Protein

    SIRT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIRT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIRT4.

    IDE;DLAT;PDHX;SLC25A5;SLC25A6;SKP2;VWA8;NDUFS2;PMPCB

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