Recombinant Human SIGLEC8 Protein, MYC/DDK-tagged

• Cat.No.: SIGLEC8-679H
• Product Overview: Recombinant protein of human sialic acid binding Ig-like lectin 8 (SIGLEC8) was expressed in HEK293 cells with C-terminal MYC/DDK tag.

Specification

• Description: Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490).
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 53.9 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Storage buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: SIGLEC8 sialic acid binding Ig-like lectin 8 [ Homo sapiens ]
• Official Symbol: SIGLEC8
• Synonyms: SIGLEC8; sialic acid binding Ig-like lectin 8; sialic acid-binding Ig-like lectin 8; MGC59785; SAF2; SIGLEC 8; SIGLEC8L; SAF-2; CDw329; sialoadhesin family member 2; SIGLEC-8
• Gene ID: 27181
• mRNA Refseq: NM_014442
• Protein Refseq: NP_055257
• MIM: 605639
• UniProt ID: Q9NYZ4