SIGLEC8
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Official Full Name
sialic acid binding Ig-like lectin 8 -
Overview
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1;transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of;the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic;tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif;homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an;association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 (PubMed;11095983)). -
Synonyms
SIGLEC8;sialic acid binding Ig-like lectin 8;sialic acid-binding Ig-like lectin 8;MGC59785;SAF2;SIGLEC 8;SIGLEC8L;SAF-2;CDw329;sialoadhesin family member 2;SIGLEC-8
Recombinant Proteins
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Mammalian cells
- His
- His&GST
- Fc
- Myc&DDK
- His&Avi
- mFc
- His&Fc&Avi
- Flag
Involved Pathway
SIGLEC8 involved in several pathways and played different roles in them. We selected most pathways SIGLEC8 participated on our site, such as Adaptive Immune System,Immune System,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIGLEC8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | ARIH2,CLTA,PJA1,SEC23A,RAET1E,GRAP2B,KIF4,TPP2,DCTN1,KIFAP3 |
| Immune System | CD300LH,CD160,HBL3,TRAF7,DEFB106A,RNF138,PANX1A,NPEPPS,CASP2,CRP |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | CLEC2B,OSCAR,CLEC2D,SIGLEC12,SIGLEC11,CD300LH,GM11711,LILRB1,CD200R4,SLAMF6 |
Protein Function
SIGLEC8 has several biochemical functions, for example, carbohydrate binding,protein binding,transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIGLEC8 itself. We selected most functions SIGLEC8 had, and list some proteins which have the same functions with SIGLEC8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane signaling receptor activity | KLRB1,LILRA1,KLRF1,TNFRSF10D,IGSF6,CR2,FZD3B,P2RX5,FZD1,EVI2A |
| carbohydrate binding | PRG2,LGALS2A,EMC7,HBL4,CDIPT,CD209C,CHODL,FCN1,SIGLEC14,LGALS2B |
| protein binding | KLF3,COMTD1,RCC1,COMMD3,MAPRE2,BRD2,SPATA13,CBY1,RGS16,GAS7 |
Interacting Protein
SIGLEC8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIGLEC8 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIGLEC8.
TFF1
Resources
Research Area
EosinophilsIg-type Lectins
Dendritic Cell Activation
Dendritic Cell ITIM/ITAM Immunoreceptors
Related Services
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References
