Recombinant Human SIGLEC8 protein, hFc-tagged

• Cat.No.: SIGLEC8-138H
• Product Overview: Recombinant Human siglec 8 Protein is expressed from mammalian with a hFc Tag at the C-terminal. It contains Met17-Ala363.

Specification

• Description: Siglec-8, also known as SAF, is an approximately 75 kDa transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-8 consists of a 347 amino acid (aa) extracellular domain (ECD) with three Ig-like domains. Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid.
• Source: HEK293
• Species: Human
• Tag: Fc
• Form: Supplied as 0. 22um filtered solution in PBS (pH 7. 4).
• Molecular Mass: The protein has a predicted MW of 64. 6 kDa. Due to glycosylation, the protein migrates to 70-82KDa based on Bis-Tris PAGE result.
• Protein length: It contains Met17-Ala363.
• Endotoxin: Less than 0. 05 EU per ug by the LAL method.
• Purity: > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: SIGLEC8 sialic acid binding Ig-like lectin 8 [ Homo sapiens ]
• Official Symbol: SIGLEC8
• Synonyms: CD329 antigen; CDw329; MGC59785; SAF2; SAF2SAF-2; sialic acid binding Ig-like lectin 8; Sialoadhesin family member 2; Siglec8; Siglec-8; SIGLEC8L; SIGLEC8Lsialic acid-binding Ig-like lectin 8
• Gene ID: 27181
• mRNA Refseq: NM_014442
• Protein Refseq: NP_055257
• MIM: 605639
• UniProt ID: Q9NYZ4