Recombinant Human SGK3, GST-tagged, Active

• Cat.No.: SGK3-430H
• Product Overview: Recombinant full-length human SGK3 was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 82 kDa.

Specification

• Cat. No.: SGK3-430H
• Description: SGK3 is a member of the SGK family and encodes a phosphoprotein with a PX (phox homology) domain. PKD1 can phosphorylate and activate SGK3 in vitro. A 10-fold increase in PKD1 increases the phosphorylation status of SGK3. When expressed in human embryonic kidney cells, IGF1 and peroxide significantly activate SGK3, and the activation could be reduced by preincubation with inhibitors of PI3 kinase. A yeast 2-hybrid screen found direct interaction between human SGK3 and GSK3β. SGK3 phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels.
• Source: Sf9 insect cells using baculovirus.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: SGK3 serum/glucocorticoid regulated kinase family, member 3 [ Homo sapiens ]
• Synonyms: SGK3; serum/glucocorticoid regulated kinase family, member 3; CISK; SGK2; SGKL; DKFZp781N0293; serum/glucocorticoid regulated kinase 3; cytokine-independent survival kinase; serum/glucocorticoid regulated kinase-like; EC 2.7.11.1; Serum/glucocorticoid-regulated kinase 3; Serum/glucocorticoid-regulated kinase-like; Serine/threonine-protein kinase Sgk3
• Gene ID: 23678
• mRNA Refseq: NM_001033578
• Protein Refseq: NP_001028750
• MIM: 607591
• UniProt ID: Q96BR1
• Chromosome Location: 8q12.3-q13.1
• Function: ATP binding; nucleotide binding; phosphoinositide binding; protein binding; protein serine/threonine kinase activity; transferase activity