Recombinant Human SF3B3 Protein (F2-F1217), His/Strep tagged

• Cat.No.: SF3B3-0591H
• Product Overview: Recombinant Human 8His-StrepII-TEV-(GG)-SF3B3(F2-F1217 end) Protein was expressed in Insect cell.

Specification

• Description: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
• Source: Insect cell
• Species: Human
• Tag: His&Strep
• Form: Liquid
• Protein length: F2-F1217
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: SF3B3 splicing factor 3b, subunit 3, 130kDa [ Homo sapiens (human) ]
• Official Symbol: SF3B3
• Synonyms: SF3B3; splicing factor 3b, subunit 3, 130kDa; splicing factor 3b, subunit 3, 130kD; splicing factor 3B subunit 3; KIAA0017; RSE1; SAP130; SF3b130; SAP 130; spliceosome-associated protein 130; pre-mRNA-splicing factor SF3b 130 kDa subunit; pre-mRNA splicing factor SF3b, 130 kDa subunit; STAF130
• Gene ID: 23450
• mRNA Refseq: NM_012426
• Protein Refseq: NP_036558
• MIM: 605592
• UniProt ID: Q15393