SF3B3
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Official Full Name
splicing factor 3b, subunit 3, 130kDa -
Overview
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the introns branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. -
Synonyms
SF3B3;splicing factor 3b, subunit 3, 130kDa;splicing factor 3b, subunit 3, 130kD;splicing factor 3B subunit 3;KIAA0017;RSE1;SAP130;SF3b130;SAP 130;OTTHUMP00000174907;spliceosome-associated protein 130;pre-mRNA-splicing factor SF3b 130 kDa subunit;pre-mRNA splicing factor SF3b, 130 kDa subunit;STAF130
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Insect Cell
- HEK293T
- HEK293 Cells
- Mammalian cells
- His
- Non
- His&Strep
- His&Myc
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
SF3B3 involved in several pathways and played different roles in them. We selected most pathways SF3B3 participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with SF3B3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | TRA2A,SRSF7A,PRPF18,SF3A1,RBMX,SRSF5,HNRNPA1,SF3B5,SRSF5B,PRPF40A |
Protein Function
SF3B3 has several biochemical functions, for example, RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SF3B3 itself. We selected most functions SF3B3 had, and list some proteins which have the same functions with SF3B3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LOC149950,ZNF707,RGP1,CALCA,USP18,RPS27L,FIBPB,CXorf40A,AZIN1,UBE2V2 |
| RNA binding | KIN,HNRNPK,NANOS1,DAZL,OASL1,SRP14,KHDC1A,ETF1,SUZ12,NCL |
Interacting Protein
SF3B3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SF3B3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SF3B3.
YWHAG;ESR2;NUDCD3;b4dyc6_human;DEGS1;CFLAR;NCOR1;WBP4;SMNDC1;HSP90AB1;HCK;YWHAZ;SNRPN;RNPS1;SF3A2;Sf3a1;q96be0_human
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References
- Yang, G; Holl, TM; et al. Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies. JOURNAL OF EXPERIMENTAL MEDICINE 210:241-256(2013).
