Recombinant Human SF3B1 Protein, MYC/DDK-tagged

• Cat.No.: SF3B1-1118H
• Product Overview: Recombinant human SF3B1 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.

Specification

• Description: This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
• Molecular Mass: 15.8 kDa
• Purity: >50 ug/mL as determined by microplate BCA method
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: SF3B1 splicing factor 3b, subunit 1, 155kDa [ Homo sapiens ]
• Official Symbol: SF3B1
• Synonyms: Hsh155; MDS; PRP10; PRPF10; SAP155; SF3b155
• Gene ID: 23451
• mRNA Refseq: NM_001005526
• Protein Refseq: NP_001005526
• MIM: 605590
• UniProt ID: O75533