Recombinant Human SETMAR protein, His-tagged

• Cat.No.: SETMAR-93H
• Product Overview: Recombinant Human SETMAR, fused with N-His tag, was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 358aa(including fusion tag)
• Description: Histone methyltransferase that methylates "Lys-4" and "Lys-36" of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 "Lys-36". Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5"-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA.
• Form: 20mM Tris.Cl, 50mM NaCl, 50% Glycerol, pH9.0.
• Molecular Mass: 42.1kDa(including fusion tag)
• Applications: WB, ELISA, IP, antibody production, protein array
• Storage: Store at -80centigrade and avoid repeated freeze-thaw cycles

Gene Information

• Gene Name: SETMAR SET domain and mariner transposase fusion gene [ Homo sapiens ]
• Official Symbol: SETMAR
• Synonyms: SETMAR; SET domain and mariner transposase fusion gene; histone-lysine N-methyltransferase SETMAR; metnase; hsMar1; SET domain and mariner transposase fusion gene-containing protein; METNASE
• Gene ID: 6419
• mRNA Refseq: NM_001243723
• Protein Refseq: NP_001230652
• MIM: 609834
• UniProt ID: Q53H47
• Chromosome Location: 3p26.2
• Pathway: Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem
• Function: endonuclease activity; histone-lysine N-methyltransferase activity; hydrolase activity; metal ion binding; methyltransferase activity; protein binding; protein homodimerization activity; structure-specific DNA binding; structure-specific DNA binding; transferase activity; transposase activity; zinc ion binding