Recombinant Human SETD2 Protein, His-tagged

• Cat.No.: SETD2-116H
• Product Overview: Recombinant N-terminal His-tagged human SETD2 protein (1435-1711) was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1435-1711
• Description: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.
• Molecular Mass: 33.7 kDa
• Purity: ≥95%
• Stability: ≥ 9 months
• Storage: At -80 centigrade.
• Storage Buffer: 50 mM Tris-HCl, pH 8.0, containing 150 mM sodium chloride and 20% glycerol

Gene Information

• Gene Name: SETD2 SET domain containing 2, histone lysine methyltransferase [ Homo sapiens (human) ]
• Official Symbol: SETD2
• Synonyms: SETD2; SET domain containing 2, histone lysine methyltransferase; LLS; HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP; histone-lysine N-methyltransferase SETD2; huntingtin interacting protein 1; huntingtin yeast partner B; huntingtin-interacting protein B; lysine N-methyltransferase 3A; protein-lysine N-methyltransferase SETD2; EC 2.1.1.359
• Gene ID: 29072
• mRNA Refseq: NM_014159
• Protein Refseq: NP_054878
• MIM: 612778
• UniProt ID: Q9BYW2