Recombinant Human SET Domain Containing 2, GST-tagged

• Cat.No.: SETD2-460H
• Product Overview: Recombinant Human SETD2 (amino acids 915-1211) was expressed in anE.coliexpression system with N-terminal GST tag. MW=59.7 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 915-1211 a.a.
• Description: Histone-lysine N-methyltransferase SETD2 is an enzyme that in humans is encoded by the SETD2 gene. Huntington"s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs.
• Formulated In: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol, and 3 mM DTT.
• Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Purity: > 75%.
• Stability: >6 months at –80°C.

Gene Information

• Gene Name: SETD2 SET domain containing 2 [ Homo sapiens ]
• Synonyms: SET domain containing 2; HYPB; SET2; HIF-1; KMT3A; HBP231; HSPC069; p231HBP; FLJ16420; FLJ22472; FLJ23184; FLJ45883; FLJ46217; KIAA1732; SETD2; huntingtin yeast partner B; lysine N-methyltransferase 3A; SET domain-containing protein 2; huntingtin interacting protein 1; huntingtin-interacting protein B; histone-lysine N-methyltransferase SETD2; EC 2.1.1.43; HIF1; hSET2; Huntingtin yeast partner B; Huntingtin-interacting protein 1; Huntingtin-interacting protein B; Lysine N-methyltransferase 3A
• Gene ID: 29072
• mRNA Refseq: NM_014159
• Protein Refseq: NP_054878
• MIM: 612778
• UniProt ID: Q9BYW2
• Chromosome Location: 3p21.31
• Pathway: Lysine degradation
• Function: DNA binding; histone-lysine N-methyltransferase activity; methyltransferase activity; oxidoreductase activity; protein binding; transferase activity; transition metal ion binding