Recombinant Human SEMG1, His-tagged

• Cat.No.: SEMG1-7760H
• Product Overview: Recombinant Human Semenogelin1/SEMG1 is produced with our mammalian cells expression system in HEK293. The target protein is expressed with sequence (Gln24Thr402) of Human SEMG1 fused with a polyhistidine tag at the Cterminus.

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Description: Semenogelin1 (SEMG1) is the predominant protein in semen; it is a secretory protein involved in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. The prostatespecific antigen (PSA) protease processes SEMG1 into smaller peptides, each possibly having a separate function. In the proteolysis process, Alphainhibin92 and alphainhibin31 are produced; they inhibit the secretion of pituitary folliclestimulating hormone. At the same time, it breaks down the gel matrix, allowing the spermatozoa to move more freely.
• Form: Lyophilized from a 0.2 μM filtered solution of 20mM HacNaAc, 150mM NaCl, pH 4.5
• AA Sequence: QKGGSKGRLP SEFSQFPHGQ KGQHYSGQKG KQQTESKGSF SIQYTYHVDA NDHDQSRKSQ QYDLNALHK TTKSQRHLGG SQQLLHNKQE GRDHDKSKGH FHRVVIHHKG GKAHRGTQNP S QDQGNSPS GKGISSQYSN TEERLWVHGL SKEQTSVSGA QKGRKQGGSQ SSYVLQTEEL VA NKQQRET KNSHQNKGHY QNVVEVREEH SSKVQTSLCP AHQDKLQHGS KDIFSTQDEL LVY NKNQHQ TKNLNQDQQH
• Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
• Notes: For research use only.
• Storage: Lyophilized protein should be stored at less than 20°C. though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C. for 2-7 days.Aliquots of reconstituted samples are stable at less than 20°C. for 3 months.

Gene Information

• Gene Name: SEMG1 semenogelin I [ Homo sapiens ]
• Official Symbol: SEMG1
• Synonyms: SEMG1; semenogelin I; SEMG; semenogelin-1; cancer/testis antigen 103; CT103; semen coagulating protein; SGI; dJ172H20.2; FLJ78262; MGC14719
• Gene ID: 6406
• mRNA Refseq: NM_003007
• Protein Refseq: NP_002998
• MIM: 182140
• UniProt ID: P04279
• Chromosome Location: 20q12-q13.2
• Pathway: Amyloids, organism-specific biosystem; Disease, organism-specific biosystem
• Function: structural molecule activity