Recombinant Human SCGB1A1

• Cat.No.: SCGB1A1-29817TH
• Product Overview: Recombinant full length Human Uteroglobin with a proprietary tag: predicted molecular weight 35.42 kDa.

Specification

• Description: This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma.
• Protein length: 70 amino acids
• Molecular Weight: 35.420kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).
• Biological activity: useful for Antibody Production and Protein Array
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.31% GlutathioneNote: Glutathione is reduced
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: EICPSFQRVIETLLMDTPSSYEAAM ELFSPDQDMREAGAQLKKLVDTLPQ KPRESIIKLMEKIAQSSLCN
• Sequence Similarities: Belongs to the secretoglobin family.
• Tag: Non

Gene Information

• Gene Name: SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) [ Homo sapiens ]
• Official Symbol: SCGB1A1
• Synonyms: SCGB1A1; secretoglobin, family 1A, member 1 (uteroglobin); UGB, uteroglobin; uteroglobin; CC10; CC16; CCSP; Uteroglobin (Clara cell specific 10 kD protein)
• Gene ID: 7356
• mRNA Refseq: NM_003357
• Protein Refseq: NP_003348
• MIM: 192020
• Uniprot ID: P11684
• Chromosome Location: 11q12.3
• Pathway: FOXA1 transcription factor network, organism-specific biosystem; Prostaglandin Synthesis and Regulation, organism-specific biosystem
• Function: binding; phospholipase A2 inhibitor activity

Reviews

02/07/2022

Precise antibody validation, enhances our immunoprecipitation accuracy.

06/07/2019

Efficient protein purification, delivers high yield and purity consistently.

03/25/2019

Timely protein expression optimization, greatly boosts our research efforts.

Q&As

How does SCGB1A1 influence the response of lung tissue to environmental pollutants and allergens?

SCGB1A1 helps protect lung tissue from environmental pollutants and allergens, reducing the risk of damage and inflammation.

What are the mechanisms by which SCGB1A1 modulates immune cell recruitment and activation in the lungs?

SCGB1A1 influences immune cell behavior in the lungs, affecting responses to infections and inflammation.

How does SCGB1A1 (Secretoglobin Family 1A Member 1) function in respiratory tract defense and lung homeostasis?

SCGB1A1 is important for respiratory defense, contributing to the maintenance of lung health and protection against irritants.

What is the impact of SCGB1A1 in asthma and chronic obstructive pulmonary disease (COPD) pathogenesis?

SCGB1A1 is implicated in the pathogenesis of asthma and COPD, influencing airway inflammation and reactivity.

How do alterations in SCGB1A1 expression or function affect respiratory infections and healing after lung injury?

Changes in SCGB1A1 expression can impact the body's ability to fight respiratory infections and heal after lung injuries.

What role does SCGB1A1 play in modulating inflammatory responses in chronic lung diseases?

SCGB1A1 modulates inflammation in chronic lung conditions, potentially impacting disease progression.

How does SCGB1A1 contribute to mucus production and airway protection?

SCGB1A1 plays a role in mucus production, essential for trapping and clearing pathogens and particles from the airways.