Recombinant Human SAT1, His-tagged

• Cat.No.: SAT1-189H
• Product Overview: Recombinant human SAT-1, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography. MW = 22.1 kDa (191aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Diamine N-acetyltransferase 1(or Spermidine/spermine-N1-acetyltransferase, SSAT1), as known as SAT-1, is a polyamine catabolic enzyme which catalyzes the acetylation of polyamines. This protein plays an important role in polyamine homoeostasis, since acetylated products are either excreted from the cell or oxidized by acetylpolyamine oxidase. A variety of other effects of increased SAT-1 activity include death of pancreatic cells, blockage of regenerative tissue growth, behavioral changes, keratosis follicularis spinulosa decalvans(KFSD), and hair loss.
• Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MAKFVIRPAT AADCSDILRL IKELAKYEYM EEQVILTEKD LLEDGFGEHP FYHCLVAEVP KEHWTPEGHS IVGFAMYYFT YDPWIGKLLY LEDFFVMSDY RGFGIGSEIL KNLSQVAMRC RCSSMHFLVA EWNEPSINFY KRRGASDLSS EEGWRLFKID KEYLLKMATE E.
• Form: Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing, 10% glycerol.
• Purity: > 95% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: SAT1 spermidine/spermine N1-acetyltransferase 1 [ Homo sapiens ]
• Synonyms: SAT1; spermidine/spermine N1-acetyltransferase 1; SAT; DC21; KFSD; SSAT; KFSDX; SSAT-1; diamine acetyltransferase 1; spermidine/spermine N1-acetyltransferase alpha; EC 2.3.1.57;Putrescine acetyltransferase; Polyamine N-acetyltransferase 1; OTTHUMP00000023061; spermidine/spermine N1-acetyltransferase; spermidine/spermine N1-acetyltransferase 1; Spermidine/spermine N(1)-acetyltransferase 1
• Gene ID: 6303
• mRNA Refseq: NM_002970
• Protein Refseq: NP_002961
• MIM: 313020
• UniProt ID: P21673
• Chromosome Location: Xp22.1
• Pathway: Arginine and proline metabolism; Metabolic pathways; Metabolism of amino acids; Metabolism of polyamines
• Function: acyltransferase activity; diamine N-acetyltransferase activity; protein binding; transferase activity