Recombinant Human SAP130 protein, MYC/DDK-tagged

• Cat.No.: SAP130-2509H
• Product Overview: Recombinant Human SAP130 fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 135.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: SAP130 Sin3A-associated protein, 130kDa [ Homo sapiens ]
• Official Symbol: SAP130
• Synonyms: SAP130; Sin3A-associated protein, 130kDa; sin3A associated protein, 130kDa; histone deacetylase complex subunit SAP130; FLJ12761; mSin3A-associated protein 130; Sin3-associated polypeptide p130; 130 kDa Sin3-associated polypeptide
• Gene ID: 79595
• mRNA Refseq: NM_001145928
• Protein Refseq: NP_001139400
• MIM: 609697
• UniProt ID: Q9H0E3
• Chromosome Location: 2q14.3
• Function: contributes_to histone acetyltransferase activity; transcription coactivator activity