Recombinant Human RYK, GST-tagged

• Cat.No.: RYK-262H
• Product Overview: Recombinant human RYK (255-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: RYK or receptor-like tyrosine kinase is an atypical member of the family of growth factor receptor protein tyrosine kinases. RYK differs from other receptor tyrosine kinases at a number of conserved residues in the activation and nucleotide binding domains. RYK has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. RYK is involved in stimulating Wnt signaling pathways such as the regulation of axon path finding.
• Source: Sf9 insect cells using baculovirus
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tis-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~66 kDa
• Purity: >90% by densitometry
• Applications: Western Blot
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μl
• Protein length: 255-end a.a.

Gene Information

• Gene Name: RYK receptor-like tyrosine kinase [ Homo sapiens ]
• Official Symbol: RYK
• Synonyms: RYK; receptor-like tyrosine kinase; JTK5A, JTK5A protein tyrosine kinase , RYK receptor like tyrosine kinase; tyrosine-protein kinase RYK; D3S3195; JTK5; RYK1; hydroxyaryl-protein kinase; JTK5A protein tyrosine kinase; RYK receptor-like tyrosine kinase; JTK5A
• Gene ID: 6259
• mRNA Refseq: NM_001005861
• Protein Refseq: NP_001005861
• MIM: 600524
• UniProt ID: P34925
• Chromosome Location: 3q22.1
• Pathway: Wnt signaling network, organism-specific biosystem
• Function: ATP binding; Wnt-protein binding; frizzled binding; nucleotide binding; protein binding; NOT protein tyrosine kinase activity; receptor activity; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity