RYK

  • Official Full Name

    receptor-like tyrosine kinase

  • Overview

    The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms.

  • Synonyms

    RYK;receptor-like tyrosine kinase;JTK5A, JTK5A protein tyrosine kinase , RYK receptor like tyrosine kinase;tyrosine-protein kinase RYK;D3S3195;JTK5;RYK1;hydroxyaryl-protein kinase;JTK5A protein tyrosine kinase;RYK receptor-like tyrosine kinase

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • E.coli
  • CHO
  • Sf9 Insect Cell
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • E.coli expression system
  • HEK293T
  • His
  • Fc
  • GST
  • Non
  • His&Flag
  • His&T7
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
RYK-3895H Recombinant Human RYK protein, His-tagged E.coli Human His 261-610 aa
RYK-633H Active Recombinant Human RYK, Fc Chimera CHO Human Fc
RYK-262H Recombinant Human RYK, GST-tagged Sf9 Insect Cell Human GST 255-end a.a.
RYK-31340TH Recombinant Human RYK Wheat Germ Human Non 110 amino acids
RYK-5445Z Recombinant Zebrafish RYK Mammalian Cell Zebrafish His
RYK-694H Recombinant Human RYK Protein, DDK/His-tagged HEK293 Human His&Flag 26-224 a.a.
RFL18925HF Recombinant Full Length Human Tyrosine-Protein Kinase Ryk(Ryk) Protein, His-Tagged E.coli expression system Human His Full L. Full Length of Mature Protein (26-607)
RYK-1937H Recombinant Human RYK protein, His & T7-tagged E.coli Human His&T7 Lys308~Cys570
Ryk-1938M Recombinant Mouse Ryk protein, His & T7-tagged E.coli Mouse His&T7 Thr287~Ile533
RYK-2012H Recombinant Human RYK Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
Ryk-5663M Recombinant Mouse Ryk Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
RYK-6209H Recombinant Human RYK Protein (Leu308-Pro568), N-His tagged E.coli Human His Leu308-Pro568
RYK-634H Recombinant Human RYK protein, hFc-tagged HEK293 Human Fc Met1-Arg227

    Involved Pathway

    RYK involved in several pathways and played different roles in them. We selected most pathways RYK participated on our site, such as Beta-catenin independent WNT signaling,PCP/CE pathway,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with RYK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PCP/CE pathway ROR1,ROR2,PRICKLE1B,PRICKLE1
    Wnt signaling network RSPO1,ATP6AP2,CTHRC1,IGFBP4,WIF1
    TCF dependent signaling in response to WNT SOX13,RSPO4,ZNRF3,SOX9B,RSPO1,TLE3B,SRY,HECW1,LGR5,RNF43
    Beta-catenin independent WNT signaling MOV10,AP2S1,AP2M1,AGO1,ITPR2,AGO2,CLTA,DVL1,ROR2,CLTB
    Signaling by Wnt RSPO4,PYGO1,SOX32,RSPO3,RSPO1,BCL9,RNF43,KREMEN2,SOX9B,FMNL3
    Signal Transduction GPR37B,ARHGAP40,RLBP1A,VIP,SEPT7,GPR39,ANXA1C,CSNK1G2,TAS2R3,RGS1

    Protein Function

    RYK has several biochemical functions, for example, ATP binding,protein binding,NOT protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RYK itself. We selected most functions RYK had, and list some proteins which have the same functions with RYK. You can find most of the proteins on our site.

    Function Related Protein
    NOT protein tyrosine kinase activity KLHL8,TWF1,ERBB3
    ATP binding TOP2A,MAGI1,EPHA10,CSF1RA,CLK4,PFKFB3,MATK,HSPA8,DYNC1LI1,SRX1
    protein binding VAPA,DAPK2,WDYHV1,ARL4D,EPHA7,IGFBP2,RYR1,COL17A1,TRIM16,TEX11
    transmembrane signaling receptor activity DNER,CLEC2D,EDAR,CD3G,CR2,TLR1,FZD9B,FZD7A,TLR2-2,FCGR2C
    transmembrane receptor protein tyrosine kinase activity ERBB4A,ROS1,ERBB3A,TYRO3,MERTK,IGF1RB,FGFR1B,NTRK3A,ALK,MUSK

    Interacting Protein

    RYK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RYK here. Most of them are supplied by our site. Hope this information will be useful for your research of RYK.

    CFTR

    Resources

    Research Area

    Receptor Tyrosine Kinases (RTKs) in the Akt Pathway
    Wnt Receptors

    References

    • Cummings, CT; DeRyckere, D; et al. Molecular Pathways: MERTK Signaling in Cancer. CLINICAL CANCER RESEARCH 19:5275-5280(2013).
    • Halford, MM; Macheda, ML; et al. A Fully Human Inhibitory Monoclonal Antibody to the Wnt Receptor RYK. PLOS ONE 8:-(2013).

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