Recombinant Human RuvB-like 1 (E. coli), His-tagged

• Cat.No.: RUVBL1-2733H
• Product Overview: Recombinant RUVBL1 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 52.3 kDa (476aa), confirmed by MALDI-TOF.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: RUVBL1, also known as TIP49A, is a component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This complex may be required for the activation of transcriptional programs associated with oncogene and proto oncogene mediated growth induction, tumor suppressor mediated growth arrest.
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MKIEEVKSTT KTQRIASHSH VKGLGLDESG LAKQAASGLV GQENAREACG VIVELIKSKK MAGRAVLLAG PPGTGKTALA LAIAQELGSK VPFCPMVGSE VYSTEIKKTE VLMENFRRAI GLRIKETKEV YEGEVTELTP CETENPMGGY GKTISHVIIG LKTAKGTKQL KLDPSIFESL QKERVEAGDV IYIEANSGAV KRQGRCDTYA TEFDLEAEEY VPLPKGDVHK KKEIIQDVTL HDLDVANARP QGGQDILSMM GQLMKPKKTE ITDKLRGEIN KVVNKYIDQG IAELVPGVLF VDEVHMLDIE CFTYLHRALE SSIAPIVIFA SNRGNCVIRG TEDITSPHGI PLDLLDRVMI IRTMLYTPQE MKQIIKIRAQ TEGINISEEA LNHLGEIGTK TTLRYSVQLL TPANLLAKIN GKDSIEKEHV EEISELFYDA KSSAKILADQ QDKYMK
• Form: Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl, 5mM DTT, 20% glycerol.
• Purity: > 95% by SDS – PAGE.
• Concentration: 0.5 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: RUVBL1 RuvB-like 1 (E. coli) [ Homo sapiens ]
• Synonyms: RUVBL1; RuvB-like 1 (E. coli); RVB1; TIH1; ECP54; TIP49; INO80H; NMP238; PONTIN; TIP49A; Pontin52; ruvB-like 1; ECP-54; NMP 238; pontin 52; TAP54-alpha; OTTHUMP00000216128; INO80 complex subunit H; nuclear matrix protein 238; RuvB (E coli homolog)-like 1; 49 kDa TBP-interacting protein; TIP60-associated protein 54-alpha; 54 kDa erythrocyte cytosolic protein; TATA binding protein interacting protein 49 kDa; 49 kDa TATA box-binding protein-interacting protein; EC 3.6.1.-; EC 3.6.4.12
• Gene ID: 8607
• mRNA Refseq: NM_003707
• Protein Refseq: NP_003698
• MIM: 603449
• UniProt ID: Q9Y265
• Chromosome Location: 3q21
• Pathway: Wnt signaling pathway
• Function: ATP binding; NOT ATPase activity; DNA helicase activity; hydrolase activity; nucleotide binding; protein binding