Recombinant Human RPS6KA1, GST-tagged, Active

• Cat.No.: RPS6KA1-424H
• Product Overview: Recombinant full-length human RPS6KA1 was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=108kDa.

Specification

• Cat. No.: RPS6KA1-424H
• Description: RSK1 is a member of the RSK (ribosomal S6 kinase) family that are growth factor-regulated serine/threonine kinases. RSK1 contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. RSK1 encodes a predicted 735-amino acid protein containing 2 distinct consensus ATP-binding site sequences. RSK1 transcript is present in lymphocytes, skeletal muscle, liver, and adipose tissue. RSKs are implicated in the activation of the mitogen-activated kinase (MAPK) cascade and the stimulation of cell proliferation and differentiation.
• Source: Sf9 insect cells using baculovirus.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• nullValue_other: Long-term potentiation; MAPK signaling pathway; Neurotrophin signaling pathway; Progesterone-mediated oocyte maturation; mTOR signaling pathway; Signalling by NGF

Gene Information

• Gene Name: RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 [ Homo sapiens ]
• Synonyms: RPS6KA1; ribosomal protein S6 kinase, 90kDa, polypeptide 1; S6K-alpha 1; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1); p90-RSK 1; ribosomal protein S6 kinase alpha 1; RSK; HU-1; RSK1; MAPKAPK1A; EC 2.7.11.1
• Gene ID: 6195
• mRNA Refseq: NM_001006665
• Protein Refseq: NP_001006666
• MIM: 601684
• UniProt ID: Q15418
• Chromosome Location: 1p
• Function: ATP binding; magnesium ion binding; nucleotide binding; protein binding; transferase activity; protein serine/threonine kinase activity