Recombinant Human RNF168 cell lysate

• Cat.No.: RNF168-1520HCL

Specification

• Description: The complex repair response elicited by DNA double-strand breaks (DSBs) includes recruitment of several DNA repair proteins and ubiquitination of H2A-type histones (see MIM 142720). RNF168 is an E3 ubiquitin ligase critical for DSB repair (Stewart et al., 2009 [PubMed 19203578]).
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot
• Tag: Non

Gene Information

• Gene Name: RNF168 ring finger protein 168, E3 ubiquitin protein ligase [ Homo sapiens ]
• Official Symbol: RNF168
• Synonyms: RNF168; ring finger protein 168, E3 ubiquitin protein ligase; ring finger protein 168; E3 ubiquitin-protein ligase RNF168; FLJ35794; FLJ39749
• Gene ID: 165918
• mRNA Refseq: NM_152617
• Protein Refseq: NP_689830
• MIM: 612688
• UniProt ID: Q8IYW5
• Chromosome Location: 3q29
• Function: chromatin binding; histone binding; ligase activity; metal ion binding; protein binding; ubiquitin binding; ubiquitin-protein ligase activity; zinc ion binding

Reviews

10/04/2020

Not only does it provide reliable and consistent results due to its high quality and purity, but it also holds significant value in understanding cellular processes and disease mechanisms.

09/03/2017

This commitment to excellence ensures that researchers are provided with the most advanced and reliable tools for their investigations.

06/19/2017

the RNF168 protein offers numerous advantages in trials and research experiments.

Q&As

Are there any current clinical trials involving RNF168 protein?

Clinical trials investigating the potential use of RNF168 as a target for cancer therapy or as a biomarker for cancer prognosis may be underway, but specific details would need to be checked.

How does RNF168 protein contribute to the DNA damage response?

RNF168 plays a role in initiating a signaling cascade that leads to the recruitment of other DNA repair proteins to the site of DNA damage, promoting repair and maintaining genomic stability.

How does RNF168 protein interact with other proteins in the DNA repair pathway?

RNF168 interacts with various proteins involved in the DNA damage response, such as 53BP1 and BRCA1, to coordinate the repair of DNA lesions and maintain genomic stability.

Can mutations in the RNF168 gene be inherited and lead to an increased risk of cancer?

Yes, inherited mutations in the RNF168 gene can increase the risk of developing certain cancers, particularly those associated with DNA damage and repair deficiencies.

Are there any known side effects or toxicities associated with modulating RNF168 activity in cancer therapy?

The potential side effects and toxicities of targeting RNF168 in cancer therapy are still being explored, and would depend on the specific approach and modality used.