Recombinant Human RNF168 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: RNF168-2245H
• Product Overview: RNF168 MS Standard C13 and N15-labeled recombinant protein (NP_689830) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 65 kDa
• AA Sequence: MALPKDAIPSLSECQCGICMEILVE PVTLPCNHTLCKPCFQSTVEKASLC CPFCRRRVSSWTRYHTRRNSLVNVE LWTIIQKHYPRECKLRASGQESEEV ADDYQPVRLLSKPGELRREYEEEIS KVAAERRASEEEENKASEEYIQRLL AEEEEEEKRQAEKRRRAMEEQLKSD EELARKLSIDINNFCEGSISASPLN SRKSDPVTPKSEKKSKNKQRNTGDI QKYLTPKSQFGSASHSEAVQEVRKD SVSKDIDSSDRKSPTGQDTEIEDMP TLSPQISLGVGEQGADSSIESPMPW LCACGAEWYHEGNVKTRPSNHGKEL CVLSHERPKTRVPYSKETAVMPCGR TESGCAPTSGVTQTNGNNTGETENE ESCLLISKEISKRKNQESSFEAVKD PCFSAKRRKVSPESSPDQEETEINF TQKLIDLEHLLFERHKQEEQDRLLA LQLQKEVDKEQMVPNRQKGSPDEYH LRATSSPPDKVLNGQRKNPKDGNFK RQTHTKHPTPERGSRDKNRQVSLKM QLKQSVNRRKMPNSTRDHCKVSKSA HSLQPSISQKSVFQMFQRCTKTRTR PLEQKLISEEDLAANDILDYKDDDD KV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: RNF168 ring finger protein 168 [ Homo sapiens (human) ]
• Official Symbol: RNF168
• Synonyms: RNF168; ring finger protein 168, E3 ubiquitin protein ligase; ring finger protein 168; E3 ubiquitin-protein ligase RNF168; FLJ35794; FLJ39749
• Gene ID: 165918
• mRNA Refseq: NM_152617
• Protein Refseq: NP_689830
• MIM: 612688
• UniProt ID: Q8IYW5

Reviews

10/04/2020

Not only does it provide reliable and consistent results due to its high quality and purity, but it also holds significant value in understanding cellular processes and disease mechanisms.

09/03/2017

This commitment to excellence ensures that researchers are provided with the most advanced and reliable tools for their investigations.

06/19/2017

the RNF168 protein offers numerous advantages in trials and research experiments.

Q&As

Are there any current clinical trials involving RNF168 protein?

Clinical trials investigating the potential use of RNF168 as a target for cancer therapy or as a biomarker for cancer prognosis may be underway, but specific details would need to be checked.

How does RNF168 protein contribute to the DNA damage response?

RNF168 plays a role in initiating a signaling cascade that leads to the recruitment of other DNA repair proteins to the site of DNA damage, promoting repair and maintaining genomic stability.

How does RNF168 protein interact with other proteins in the DNA repair pathway?

RNF168 interacts with various proteins involved in the DNA damage response, such as 53BP1 and BRCA1, to coordinate the repair of DNA lesions and maintain genomic stability.

Can mutations in the RNF168 gene be inherited and lead to an increased risk of cancer?

Yes, inherited mutations in the RNF168 gene can increase the risk of developing certain cancers, particularly those associated with DNA damage and repair deficiencies.

Are there any known side effects or toxicities associated with modulating RNF168 activity in cancer therapy?

The potential side effects and toxicities of targeting RNF168 in cancer therapy are still being explored, and would depend on the specific approach and modality used.