Recombinant Human RNASEH2B Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: RNASEH2B-1331H
• Product Overview: RNASEH2B MS Standard C13 and N15-labeled recombinant protein (NP_001135751) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2).
• Molecular Mass: 28.8 kDa
• AA Sequence: MAAGVDCGDGVGARQHVFLVSEYLKDASKKMKNGLMFVKLVNPCSGEGAIYLFNMCLQQLFEVKVFKEKHHSWFINQSVQSGGLLHFATPVDPLFLLLHYLIKADKEGKFQPLDQVVVDNVFPNCILLLKLPGLEKLLHHVTEEKGNPEIDNKKYYKYSKEKTLKWLEKKVNQTVAALKTNNVNVSSRVQSTAFFSGDQASTDKEEDYIRYAHGLISDYIPKELSDDLSKYLKLPEPSASLPNPPSKMAAQRQKRGKTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: RNASEH2B ribonuclease H2 subunit B [ Homo sapiens (human) ]
• Official Symbol: RNASEH2B
• Synonyms: RNASEH2B; ribonuclease H2 subunit B; AGS2; DLEU8; ribonuclease H2 subunit B; Aicardi-Goutieres syndrome 2 protein; RNase H2 subunit B; deleted in lymphocytic leukemia 8; ribonuclease HI subunit B
• Gene ID: 79621
• mRNA Refseq: NM_001142279
• Protein Refseq: NP_001135751
• MIM: 610326
• UniProt ID: Q5TBB1