RNASEH2B
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Official Full Name
ribonuclease H2, subunit B -
Overview
RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). -
Synonyms
RNASEH2B;AGS2;DLEU8;ribonuclease H2, subunit B;ribonuclease H2 subunit B;RNase H2 subunit B;ribonuclease HI subunit B;deleted in lymphocytic leukemia 8;Aicardi-Goutieres syndrome 2 protein
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Myc&DDK
- His&Fc&Avi
Involved Pathway
RNASEH2B involved in several pathways and played different roles in them. We selected most pathways RNASEH2B participated on our site, such as DNA replication, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNASEH2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Replication | RPA4,POLE3,SSBP1,PRIM1,RFC3,MCM6,POLD2,POLE,MCM2,PCNA |
Protein Function
RNASEH2B has several biochemical functions, for example, RNA-DNA hybrid ribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RNASEH2B itself. We selected most functions RNASEH2B had, and list some proteins which have the same functions with RNASEH2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA-DNA hybrid ribonuclease activity | RNASEH2C,RNASEH2A,FEN1,EXO1,RNASEH1,APEX1 |
Interacting Protein
RNASEH2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNASEH2B here. Most of them are supplied by our site. Hope this information will be useful for your research of RNASEH2B.
DAB2IP;SAP18;ARPC5;BRINP1;RNASEH2A;STAMBP;CLPTM1;HIVEP1;RRM1;YWHAQ;FOXM1;PSMD5;RABGAP1L;ZMYM1;RNF213;BCOR;C1orf52;THOC2;RNASEH2C
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References
- Wang, YF; Fang, R; et al. Identification of host proteins interacting with the integrin-like A domain of Toxoplasma gondii micronemal protein MIC2 by yeast-two-hybrid screening. PARASITES & VECTORS 7:-(2014).
- Kind, B; Muster, B; et al. Altered spatio-temporal dynamics of RNase H2 complex assembly at replication and repair sites in Aicardi-Goutieres syndrome. HUMAN MOLECULAR GENETICS 23:5950-5960(2014).
