Recombinant Human RNASEH2B protein, Myc/DDK-tagged

• Cat.No.: RNASEH2B-2328H
• Product Overview: Recombinant Human RNASEH2B protein transcript variant 2, fused to Myc/DDK-tag at C-terminus, was expressed in human 293 cells (HEK293) and purified through anti-DDK affinity column followed by conventional chromatography steps.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2).
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
• Molecular Mass: 28.8 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 μg/mL as determined by microplate BCA method

Gene Information

• Gene Name: RNASEH2B
• Official Symbol: RNASEH2B
• Synonyms: AGS2; DLEU8
• Gene ID: 79621
• mRNA Refseq: NM_001142279.2
• Protein Refseq: NP_001135751.1
• MIM: 610326
• UniProt ID: Q5TBB1