Recombinant Human Regulator Of Calcineurin 2, His-tagged

• Cat.No.: RCAN2-4750H
• Product Overview: Recombinant human RCAN2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: Human
• Tag: His
• Description: Calcipressin-2, also known as RCAN2, belonging to the RCAN (Regulator of calcineurin) family modulate the activity of Calcineurin through a valine-rich region within their carboxyl tail. RCANs compete with NFAT(nuclear factor of activated T-cells) for binding to the same docking site in calcineurin, which results in either inhibition or activation of calcineurin activity. RCAN2 is a Ca(2+) dependent protein phosphatase that is involed in several neuornal functions.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 0.2M NaCl
• Molecular Weight: 24.1 kDa (217aa), confirmed by MALDI-TOF
• Purity: > 85% by SDS - PAGE
• Concentration: 0.5 mg/ml (determined by Bradford assay)
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MPAPSMDCDV STLVACVVDV EVFTNQEVKE KFEGLFRTYD DCVTFQLFKS FRRVRINFSN PKSAARARIE LHETQFRGKK LKLYFAQVQT PETDGDKLHL APPQPAKQFL ISPPSSPPVG WQPINDATPV LNYDLLYAVA KLGPGEKYEL HAGTESTPSV VVHVCDSDIE EEEDPKTSPK PKIIQTRRPG LPPSVSN
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Pathways: Calcium signaling in the CD4+ TCR pathway; Role of Calcineurin-dependent NFAT signaling in lymphocytes

Gene Information

• Gene Name: RCAN2 regulator of calcineurin 2 [ Homo sapiens ]
• Official Symbol: RCAN2
• Synonyms: RCAN2; CSP2; RCN2; MCIP2; ZAKI4; hRCN2; ZAKI-4; DSCR1L1; regulator of calcineurin 2; calcipressin-2; OTTHUMP00000016544; Down syndrome candidate region 1-like 1; thyroid hormone-responsive protein ZAKI-4; Down syndrome critical region gene 1-like 1; thyroid hormone-responsive (skin fibroblasts); myocyte-enriched calcineurin-interacting protein 2; Calcipressin 2 (Thyroid hormone-responsive protein ZAKI-4) (Down syndrome candidate region 1-like 1) (Myocyte-enriched calcineurin interacting protein 2) (MCIP2)
• Gene ID: 10231
• mRNA Refseq: NM_005822
• Protein Refseq: NP_005813
• MIM: 604876
• UniProt ID: Q14206
• Chromosome Location: 6p12.3
• Function: nucleotide binding; protein phosphatase 2B binding