Recombinant Human REG4, His-tagged

• Cat.No.: REG4-426H
• Product Overview: A DNA sequence encoding the human REG4 (NP_001152824.1) (Met 1-Pro 158) was expressed, with a polyhistidine tag at the C-terminus.

Specification

• Species: Human
• Source: Human Cells
• Tag: His
• Protein Length: 1-158 a.a.
• Description: Regenerating islet-derived protein 4, also known as REG-like protein, REG4, GISP and RELP, is a secreted protein which contains one C-type lectin domain. REG4 is involved in inflammatory and metaplastic responses of the gastrointestinal epithelium. REG4 is highly expressed in the gastrointestinal tract including the duodenum, jejunum, ileum, ileocecum, appendix, descending colon, pancreas and small intestine. It is weakly expressed in normal colon and stomach and strongly expressed in most colorectal tumors than in normal colon. It is also preferentialy expressed in mucinous tumors and in some cases neuro-endocrine tumors. REG4 protein overexpression is associated with an unfavorable response to preoperative chemoradiotherapy and may be used as a predictive biomarker clinically. REG4 is also a promising tumor marker to screen early-stage Pancreatic ductal adenocarcinoma (PDAC), and neutralization of REG4 by the antibody may offer novel potential tools for the treatment of PDAC.
• Predicted N Terminal: Ala 26
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.
• Molecular Mass: The recombinant human REG4 consists of 147 amino acids and predictes a molecular mass of 17.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh REG4 is approximately 17 and 21 kDa due to different glycosylation.
• Endotoxin: < 1.0 eu per μg of the protein as determined by the lal
• Purity: >85 % as determined by SDS-PAGE
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: REG4 regenerating islet-derived family, member 4 [ Homo sapiens ]
• Official Symbol: REG4
• Synonyms: REG4; regenerating islet-derived family, member 4; regenerating islet-derived protein 4; gastrointestinal secretory protein; GISP; REG IV; regenerating gene type IV; RELP; REG-4; reg IV; REG-like protein; regenerating islet-derived protein IV; REG-IV
• Gene ID: 83998
• mRNA Refseq: NM_001159352
• Protein Refseq: NP_001152824
• MIM: 609846
• UniProt ID: Q9BYZ8
• Chromosome Location: 1p13.1-p12
• Function: binding; sugar binding