Recombinant Human RAN Guanine Nucleotide Release Factor, His-tagged

• Cat.No.: RANGRF-6941H
• Product Overview: Recombinant human RANGRF protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-186aa
• Description: RANGRF is a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants.
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.15M NaCl, 1mM DTT.
• Molecular Mass: 23.0 kDa (210aa), confirmed by MALDI-TOF
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMEPTRD CPLFGGAFSA ILPMGAIDVS DLRPVPDNQE VFCHPVTDQS LIVELLELQA HVRGEAAARY HFEDVGGVQG ARAVHVESVQ PLSLENLALR GRCQEAWVLS GKQQIAKENQ QVAKDVTLHQ ALLRLPQYQT DLLLTFNQPP PDNRSSLGPE NLSPAPWSLG DFEQLVTSLT LHDPNIFGPQ
• Purity: >90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: RANGRF RAN guanine nucleotide release factor [ Homo sapiens ]
• Official Symbol: RANGRF
• Synonyms: RANGRF; RAN guanine nucleotide release factor; ran guanine nucleotide release factor; HSPC165; HSPC236; MOG1; MOG1 homolog (S. cerevisiae); RANGNRF; MOG1 homolog; ran-binding protein MOG1; MGC110973; DKFZp686F02139
• Gene ID: 29098
• mRNA Refseq: NM_001177801
• Protein Refseq: NP_001171272
• MIM: 607954
• UniProt ID: Q9HD47
• Chromosome Location: 17p13
• Function: guanyl-nucleotide exchange factor activity