Recombinant Human PTPN18 Protein, His&GST-tagged

• Cat.No.: PTPN18-2003H
• Product Overview: Recombinant Human PTPN18 Protein (Ala311-Val460) with N-His&GST tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: GST&His
• Protein Length: Ala311-Val460
• Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 45.1 kDa
  Accurate Molecular Mass: 48 kDa
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) [ Homo sapiens (human) ]
• Official Symbol: PTPN18
• Synonyms: PTPN18; protein tyrosine phosphatase non-receptor type 18; BDP1; PTP-HSCF; tyrosine-protein phosphatase non-receptor type 18; brain-derived phosphatase; protein tyrosine phosphatase, non-receptor type 18 (brain-derived); EC 3.1.3.48
• Gene ID: 26469
• mRNA Refseq: NM_014369
• Protein Refseq: NP_055184
• MIM: 606587
• UniProt ID: Q99952