Recombinant Human PTPN18 cell lysate

• Cat.No.: PTPN18-1437HCL

Specification

• Species: Human
• Tag: Non
• Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene.
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) [ Homo sapiens ]
• Official Symbol: PTPN18
• Synonyms: BDP1; PTP-HSCF
• Gene ID: 26469
• mRNA Refseq: NM_014369.3
• Protein Refseq: NP_055184.2
• MIM: 606587
• UniProt ID: Q99952
• Chromosome Location: 2q21.1
• Pathway: B Cell Receptor Signaling Pathway, organism-specific biosystem
• Function: non-membrane spanning protein tyrosine phosphatase activity