Recombinant Human PTPN12, GST-tagged, Active

• Cat.No.: PTPN12-462H
• Product Overview: Recombinant human PTPN12 (1-355) was expressed inE. colicells using a N-terminal GST tag. MW = 66 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 1-355 a.a.
• Description: Protein tyrosine phosphatase-PEST (PTPN12), a ubiquitously expressed cytoplasmic tyrosine phosphatase, is thought to play an important role in cell adhesion and motility, cell migration, and signal transduction for antigen receptors in B and T lymphocytes. Signal transduction via tyrosine phosphorylation, normally fine-tuned by the concerted action of both protein tyrosine kinases and protein tyrosine phosphatases (PTPs), is a key mechanism in tumorigenesis. Studies suggest potential role for PTP-PEST in regulation of p130(cas) in mitogen- and cell adhesion-induced signaling events.
• Sequence: 1-355.
• Applications: Phosphatase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: PTPN12 protein tyrosine phosphatase, non-receptor type 12 [ Homo sapiens ]
• Synonyms: protein tyrosine phosphatase, non-receptor type 12; PTPG1; PTP-PEST; PTPN12; protein-tyrosine phosphatase G1; tyrosine-protein phosphatase non-receptor type 12; EC 3.1.3.48; OTTHUMP00000025119; Protein-tyrosine phosphatase G1
• Gene ID: 5782
• mRNA Refseq: NM_001131008
• Protein Refseq: NP_001124480
• MIM: 600079
• UniProt ID: Q05209
• Chromosome Location: 7q11.23
• Function: SH3 domain binding; hydrolase activity; protein binding; non-membrane spanning protein tyrosine phosphatase activity