Recombinant Human PTP4A2(2-167), His-tagged

• Cat.No.: PTP4A2-505H
• Product Overview: Recombinant human PTP4A2 protein(2-167) with N-terminal His tag was expressed in anE.coliexpression system, MW= 19.1 kDa.

Specification

• Cat. No.: PTP4A2-505H
• Description: Protein tyrosine phosphatase type IVA 2 is an enzyme that in humans is encoded by the PTP4A2 gene. he protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity.
• Source: E.coli.
• Purity: > 90%.
• Formulation: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 20% glycerol, and 3 mM DTT.
• Specific Activity: 0.334 pmol/min/μg, Assay conditions: enzyme was incubated in50mM Tris pH7.4, 150mM NaCl 5mM DTT, and 12.5mM PNPP as a substrate for 2h at 37°C. Absorbance was read by Tecan spectraphotometer at 405 nm wavelength.
• Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Storage: >6 months at –80°C.
• Tag: Non
• Protein length: 2-167 a.a.

Gene Information

• Gene Name: PTP4A2 protein tyrosine phosphatase type IVA, member 2 [ Homo sapiens ]
• Synonyms: PTP4A2; protein tyrosine phosphatase type IVA, member 2; HH13; OV-1; PRL2; HH7-2; PRL-2; PTP4A; HU-PP-1; PTPCAAX2; ptp-IV1a; ptp-IV1b; Protein tyrosine phosphatase type IVA 2; EC 3.1.3.48; Protein-tyrosine phosphatase 4a2; BM-008; Protein-tyrosine phosphatase of regenerating liver 2
• Gene ID: 8073
• mRNA Refseq: NM_080391
• Protein Refseq: NP_536316
• MIM: 601584
• UniProt ID: Q12974
• Chromosome Location: 1p35
• Function: prenylated protein tyrosine phosphatase activity; hydrolase activity; protein binding