PTP4A2
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Official Full Name
protein tyrosine phosphatase type IVA, member 2 -
Overview
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are;cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a;protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been;shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was;found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a;regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which;suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related;pseudogenes exist on chromosomes 11, 12 and 17. -
Synonyms
PTP4A2;protein tyrosine phosphatase type IVA, member 2;PTP4A;protein tyrosine phosphatase type IVA 2;HU PP 1;OV 1;PRL 2;ptp IV1a;PTPCAAX2;PTP(CAAXII);protein tyrosine phosphatase IVA;protein-tyrosine phosphatase 4a2;protein tyrosine phosphatase IVA2;phosphatase of regenerating liver 2;protein-tyrosine phosphatase of regenerating liver 2;HH13;OV-1;PRL2;HH7-2;PRL-2;HU-PP-1;ptp-IV1a;ptp-IV1b
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- N-His
- Mammalian Cell
- Sf9 Insect Cell
- HEK293
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PTP4A2 involved in several pathways and played different roles in them. We selected most pathways PTP4A2 participated on our site, such as Signaling events mediated by PRL, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTP4A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling events mediated by PRL | RABGGTB,RABGGTA,ATF5,PTP4A3,LRP8,PTP4A1 |
Protein Function
PTP4A2 has several biochemical functions, for example, prenylated protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTP4A2 itself. We selected most functions PTP4A2 had, and list some proteins which have the same functions with PTP4A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| prenylated protein tyrosine phosphatase activity | PTP4A3 |
Interacting Protein
PTP4A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTP4A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTP4A2.
TNFAIP8;EPHB2;FNTA;FNTB;USF2;CNNM3;PTP4A1;MLH1;Kif21b;CDK2
Resources
Research Area
Phosphatases and RegulatorsPhosphatases in the Akt Pathway
Endodermal Lineage Markers
Related Services
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References
- Wu, S; Kanda, T; et al. Knockdown of Receptor-Interacting Serine/Threonine Protein Kinase-2 (RIPK2) Affects EMT-associated Gene Expression in Human Hepatoma Cells. ANTICANCER RESEARCH 32:3775-3783(2012).
