Recombinant Human PTP4A1(2-173), His-tagged

• Cat.No.: PTP4A1-504H
• Product Overview: Recombinant human PTP4A1 protein(2-173) with N-terminal His tag was expressed in anE.coliexpression system, MW= 19.8 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 2-173 a.a.
• Description: Protein tyrosine phosphatase type IVA 1 is an enzyme that in humans is encoded by the PTP4A1 gene. The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation.
• Purity: > 90%.
• Formulation: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 20% glycerol, and 3 mM DTT.
• Specific Activity: 0.168 pmol/min/μg, Assay conditions: enzyme was incubated in50mM Tris pH7.4, 150mM NaCl 5mM DTT, and 12.5mM PNPP as a substrate for 2h at 37°C. Absorbance was read by Tecan spectraphotometer at 405 nm wavelength.
• Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Storage: >6 months at –80°C.

Gene Information

• Gene Name: PTP4A1 protein tyrosine phosphatase type IVA, member 1 [ Homo sapiens ]
• Synonyms: PTP4A1; protein tyrosine phosphatase type IVA, member 1; HH72; PRL1; PRL-1; PTPCAAX1; PTP(CAAX1); DKFZp779M0721; PTP(CAAXI); protein-tyrosine phosphatase 4a1; Protein tyrosine phosphatase IVA1; protein tyrosine phosphatase type IVA protein 1; protein-tyrosine phosphatase of regenerating liver 1; EC 3.1.3.48
• Gene ID: 7803
• mRNA Refseq: NM_003463
• Protein Refseq: NP_003454
• MIM: 601585
• UniProt ID: Q93096
• Chromosome Location: 6q12
• Function: hydrolase activity; protein tyrosine phosphatase activity