Recombinant Human Protein Kinase N2, GST-tagged, Active

• Cat.No.: PKN2-411H
• Product Overview: Recombinant full-length human PKN2 was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=145kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: PKN2 (also known as PRK2) is a Rho effector and a member of the protein kinase C superfamily of serine/threonine kinases. PKN2 is an essential regulator of both entry into mitosis and exit from cytokinesis in HeLa S3 cells. PKN2 is required for abscission of the midbody at the end of the cell division cycle and for phosphorylation and activation of Cdc25B, the phosphatase required for activation of mitotic cyclin/Cdk1 complexes at the G2/M transition. C-terminus of PKN2 could be a potential drug target for effector-specific pharmacological intervention of Rho-medicated biological processes.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: PKN2 protein kinase N2 [ Homo sapiens ]
• Synonyms: PKN2; protein kinase N2; PAK2; PRK2; Pak-2; PRKCL2; PRO2042; MGC71074; MGC150606; protein kinase C-like 2; cardiolipin-activated protein kinase Pak2; EC 2.7.11.13
• Gene ID: 5586
• mRNA Refseq: NM_006256
• Protein Refseq: NP_006247
• MIM: 602549
• UniProt ID: Q16513
• Chromosome Location: 1p22.2
• Function: ATP binding; nucleotide binding; protein kinase C activity; transferase activity