PKN2
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Official Full Name
protein kinase N2 -
Overview
The protein kinase C-related kinases (PRKs) are a subfamily of Ser/Thr-specific kinases with a catalytic domain highly homologous to the PKC family. They are effectors of Rho family GTPases and are activated by fatty acids and phospholipids in vitro. Acti -
Synonyms
PKN2;protein kinase N2;PRKCL2, protein kinase C like 2;serine/threonine-protein kinase N2;cardiolipin activated protein kinase Pak2;Pak 2;PRK2;PKN gamma;protein kinase C-like 2;protein-kinase C-related kinase 2;cardiolipin-activated protein kin;PAK2;Pak-2;PRKCL2;PRO2042
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cells
- Sf9 Cells
- HEK293
- Sf21 Cells
- GST
- His
- Non
- DDK&Myc
- Avi&Fc&His
Involved Pathway
PKN2 involved in several pathways and played different roles in them. We selected most pathways PKN2 participated on our site, such as PIK-Akt signaling pathway,Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PKN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Salmonella infection | ARPC5B,ROCK2A,MAPK8,IL8L2,IL1A,WASL,CXCL3,CD14,CCL3,NFKB1 |
| PIK-Akt signaling pathway | IFNAR1,LAMB1,THBS3,ITGA9,CCND1,IL2RG,RXRA,GSK3B,LAMA5,DDIT4 |
Protein Function
PKN2 has several biochemical functions, for example, ATP binding,RNA polymerase binding,histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PKN2 itself. We selected most functions PKN2 had, and list some proteins which have the same functions with PKN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kinase activity | CDC7,IGF1RB,STK38A,PIP5K2,AKT1,MASTL,ALPK2,CKMA,RPS6KA3B,CAMK2A |
| protein kinase C activity | PRKCD,PRKCBB,PRKCZ,PRKCDA,PRKD1,PRKCE,PRKCHA,PRKCG,PRKCH,PRKD2 |
| protein kinase activity | TNK2B,MMD,TBCK,CDK17,SBK1,GUCY2F,CAMK2D2,FASTKD2,BMPR1BB,ROCK1 |
| RNA polymerase binding | ANP32B,NEDD4,WDHD1,TAF10,GSG1,STOM,BIN1,PHRF1,RRN3,PPIB |
| protein serine/threonine kinase activity | TGFBR1B,LMTK2,PRKD2,TSSK4,GRK1A,AKT2L,MAPK8B,CSNK1E,CSNK2A2,TTK |
| ATP binding | EIF2AK2,PIP4K2C,FES,SARS,KIF15,MYH10,ULK1A,STK3,SGK196,MYO7AA |
| histone deacetylase binding | KAT2B,RFXANK,CEBPB,NRIP1,NCOR2,GMNN,MAGEA1,KPNA2,NACC2,CCND1 |
| poly(A) RNA binding | RPL3,MKI67IP,RRP9,SRSF5,PPIL4,RPL5B,XRCC5,ZCCHC9,NSA2,RPS12 |
| protein binding | MAP2K4,NUDCD2,FAM90A1,VCAN,LILRB2,CAPG,PRADC1,FANCM,SDCCAG8,HNRNPA2B1 |
Interacting Protein
PKN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PKN2.
o92972-pro_0000278753;PTPN13;NCK2;PDK1;HSP90AA1
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References
- Muller, AE; Kreiner, M; et al. Acute exercise modifies titin phosphorylation and increases cardiac myofilament stiffness. FRONTIERS IN PHYSIOLOGY 5:-(2014).
- Garcia-Arriaza, J; Gomez, CE; et al. Deletion of the Vaccinia Virus N2L Gene Encoding an Inhibitor of IRF3 Improves the Immunogenicity of Modified Vaccinia Virus Ankara Expressing HIV-1 Antigens. JOURNAL OF VIROLOGY 88:3392-3410(2014).
