Recombinant Human Protein Kinase, AMP-Activated, Beta 1 Non-Catalytic Subunit, His-tagged

Cat.No. : PRKAB1-4867H
Product Overview : Recombinant full-length human PRKAB1 (combination of A1/B1/G3 subunits) was expressed by baculovirus in Sf9 insect cells using a C-terminal His tags.
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Species : Human
Source : Sf9 Cells
Tag : His
Description : PRKAB1 (A1/B1/G3) is a member of the PRKAB1 family which are heterotrimeric proteins consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. PRKAB1 are an important energy-sensing enzyme group in the cells that monitor energy status particularly in response to stress. PRKAB1 regulate fatty acid and cholesterol synthesis by regulating the key rate-limiting enzymes acetyl-CoA carboxylase and hydroxy beta-methylglutaryl-CoA reductase. The γ subunit is dominantly expressed in skeletal muscle where it may play a key role in the regulation of energy metabolism.
Applications : Kinase Assay; Western Blot
Molecular Weight : 68kDa (A1), 38kDa (B1), 51kDa (G3)
Expression System : Sf9 insect cells using baculovirus
Form : Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol.
Specific Activity : 185 nmol/min/mg
Purity : > 70 %
Concentration : 0.1 ug/ul
Sequences : Full-length
Storage : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : AMPK signaling; Adipocytokine signaling pathway; Direct p53 effectors; Energy Metabolism; Energy dependent regulation of mTOR by LKB1-AMPK; Hypertrophic cardiomyopathy (HCM); IRS-mediated signalling; IRS-related events; Insulin receptor signalling cascade; Insulin signaling pathway; PI3K Cascade; PKB-mediated events; Regulation of AMPK activity via LKB1; Regulation of Rheb GTPase activity by AMPK; Signaling by Insulin receptor; mTOR signalling
Gene Name PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit [ Homo sapiens ]
Official Symbol PRKAB1
Synonyms PRKAB1; protein kinase, AMP-activated, beta 1 non-catalytic subunit; AMPK; HAMPKb; MGC17785; 5"-AMP-activated protein kinase subunit beta-1; AMPKb; AMPK beta 1; AMPK beta -1 chain; OTTHUMP00000239813; OTTHUMP00000239814; AMPK subunit beta-1; AMP-activated protein kinase beta subunit; 5"-AMP-activated protein kinase beta-1 subunit; protein kinase, AMP-activated, noncatalytic, beta-1
Gene ID 5564
mRNA Refseq NM_006253
Protein Refseq NP_006244
MIM 602740
UniProt ID Q9Y478
Chromosome Location 12q24.1-q24.3
Function AMP-activated protein kinase activity; cAMP-dependent protein kinase activity; protein binding; protein kinase binding

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