PRKAB1
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Official Full Name
protein kinase, AMP-activated, beta 1 non-catalytic subunit -
Overview
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008] -
Synonyms
PRKAB1;protein kinase, AMP-activated, beta 1 non-catalytic subunit;AMPK;HAMPKb;5-AMP-activated protein kinase subunit beta-1;AMPKb;AMPK beta 1;AMPK beta -1 chain;AMPK subunit beta-1;AMP-activated protein kinase beta subunit;5-AMP-activated protein kinase beta-1 subunit;protein kinase, AMP-activated, noncatalytic, beta-1
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- Sf9 Cells
- Insect Cells
- HEK293
- His
- GST
- MBP
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
PRKAB1 involved in several pathways and played different roles in them. We selected most pathways PRKAB1 participated on our site, such as FoxO signaling pathway,AMPK signaling pathway,Circadian rhythm, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Circadian rhythm | CUL1,RORB,NR1D1,PRKAG2,RBX1,CRY1,PRKAG3,FBXW11,NPAS2,BTRC |
| Adipocytokine signaling pathway | G6PC3,MAPK8B,AKT2,JAK2B,TNFRSF1B,ADIPOR2,ACSBG2,ACSBG1,MAPK10,TNFRSF1A |
| FoxO signaling pathway | GABARAPA,SMAD2,PIK3R3A,PRMT1,GADD45AA,GABARAP,FOXG1A,PRKAB1A,IKBKB,GRB2A |
| Insulin signaling pathway | BAD,KRAS,PRKAG2A,PRKAR2AA,NRAS,G6PC2,FBP1B,PRKAB2,INSRB,FLOT1A |
| Hypertrophic cardiomyopathy (HCM) | PRKAA2,ITGA2B,LAMA2,ITGB6,SGCG,TGFB2,ACTG1,ACE,CACNB3,TNNI3 |
| Non-alcoholic fatty liver disease (NAFLD) | NDUFB7,TGFB1,NDUFB9,UQCR10,PIK3CA,NDUFV2,IRS2,INS,NDUFS8,COX7A2 |
| Oxytocin signaling pathway | PRKAB2,PPP3R1,CACNB2,CAMK2B,PPP1R12A,NFATC1,PPP1CB,Adcy4,PIK3CG,ACTG1 |
| Insulin resistance | PRKCBB,MGEA5,SLC27A5,PCK2,PYGMA,NFKB1,AKT2L,PIK3R3B,PRKCBA,RPS6KB1 |
| AMPK signaling pathway | PFKFB3,ACACB,CPT1C,PIK3R2,ELAVL1,Scd1,RAB10,PPARGC1A,PIK3CA,PIK3R5 |
Protein Function
PRKAB1 has several biochemical functions, for example, AMP-activated protein kinase activity,protein binding,protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAB1 itself. We selected most functions PRKAB1 had, and list some proteins which have the same functions with PRKAB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | DOK7,FAM83B,ATG13,RICTOR,KCNQ3,CDKN2C,MAPK4,TRAP1,TCF7L2,MS4A2 |
| protein binding | NEFM,ZBTB32,ZBTB26,RPL13,LRP12,PTGIS,MASP1,SERPINA5,FKBP3,Siglec1 |
| protein kinase activity | NEK4,PKDCC,RASSF2,BMPR2B,PRKAA1,CLK4B,PRKCDA,KITB,PRKCHB,CSNK1DB |
| AMP-activated protein kinase activity | ALPK2,PRKAA1,PRKAG3,PRKAG2,PRKAA2 |
Interacting Protein
PRKAB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAB1.
PRKAA1;PRKAG1;PRKAB2;CBR1;Cidea;GRB2
PRKAB1 Related Signal Pathway
Resources
Research Area
Kinases and Phosphatases in Endothelial CellsIntracellular Kinases in the Akt Pathway
Growth Hormone/IGF-I Axis
AMPK (AMP-activated Protein Kinases)
Related Services
Related Products
References
- Brett, KE; Ferraro, ZM; et al. Prenatal physical activity and diet composition affect the expression of nutrient transporters and mTOR signaling molecules in the human placenta. PLACENTA 36:204-212(2015).
- Banerjee, S; Zagorska, A; et al. Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1 beta(MYPT1) phosphatase complex and the SCF beta TrCP E3 ubiquitin ligase. BIOCHEMICAL JOURNAL 461:233-245(2014).
