Recombinant Human Progesterone Receptor

• Cat.No.: PGR-182H
• Product Overview: Recombinant Human progesterone receptor protein expressed inE.coliencodes 412-562 amino acids and has a molecular mass of 43 kDa.

Specification

• Cat. No.: PGR-182H
• Description: The progesterone receptor (PgR) is an estrogen-regulated protein. It has been proposed that expression of PgR determination indicates a responsive estrogen receptor (ER) pathway, and therefore, may predict likely response to endocrine therapy in human breast cancer. A number of studies have shown that PgR determination provides supplementary information to ER, both in predicting response to endocrine therapy and estimating survival. PgR has proved superior to ER as a prognostic indicator in some studies.
• Source: E.coli.
• Formulation: Recombinant Human PGR at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
• Application And Suggested Dilutions: •ELISA •Inhibition Assays •Western Blotting.
• Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 43 kDa.
• Activity: Not known.
• Storage & Stability: Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
• Tag: Non
• Protein length: 412-562 a.a.

Gene Information

• Gene Name: PGR progesterone receptor [ Homo sapiens ]
• Synonyms: PGR; progesterone receptor; PR; NR3C3; Nuclear receptor subfamily 3 group C member 3
• Gene ID: 5241
• mRNA Refseq: NM_000926
• Protein Refseq: NP_000917
• MIM: 607311
• UniProt ID: P06401
• Chromosome Location: 11q22-q23
• Function: metal ion binding; protein N-terminus binding; sequence-specific DNA binding; steroid binding; steroid hormone receptor activity; transcription factor activity; zinc ion binding