PGR
-
Official Full Name
progesterone receptor -
Overview
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Jan 2011] -
Synonyms
PGR;progesterone receptor;PR;NR3C3;nuclear receptor subfamily 3 group C member 3
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Zebrafish
- Dog
- Mouse
- E.coli
- Sf9 Insect Cell
- HEK293
- Insect Cell
- Human Cell
- Mammalian Cell
- HEK293T
- Mamanlian cells
- His
- GST
- Non
- Myc&DDK
- StrepII
- His&T7
- His&GST
- His&Fc&Avi
- Flag
Involved Pathway
PGR involved in several pathways and played different roles in them. We selected most pathways PGR participated on our site, such as Oocyte meiosis,Progesterone-mediated oocyte maturation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PGR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Progesterone-mediated oocyte maturation | MAPK1,CDC27,CDC26,ADCY1B,CDC25A,MAPK8,FZR1,GNAI2B,RAF1,PIK3CA |
| Oocyte meiosis | PRKACA,RPS6KA2,RPS6KA3A,ITPR1,PPP2CA,YWHAZ,PPP2R5A,CDC27,PRKACBB,PPP1CAB |
Protein Function
PGR has several biochemical functions, for example, ATPase binding,DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PGR itself. We selected most functions PGR had, and list some proteins which have the same functions with PGR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | ZNF253,GABPA,ZNF264,PRDM5,CUX2,ATF7,JUND,KCNIP3,MITFB,NR5A2 |
| steroid hormone receptor activity | NR1H5,NR5A2,RORCA,RXRA,NR5A1B,NR2F6,NR1D2A,HNF4A,NR4A2B,OLFR78 |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | RORB,NR2E3,RXRA,NR6A1,RXRB,NR1H4,Ar,ESR2,PPARAB,NR1I3 |
| receptor binding | TRDN,KNG1,F7,ADIPOQ,ECI2,ACOT8,YES1,CADM3,FGF24,GFRA1 |
| ATPase binding | PIH1D1,DRD1,GABARAPL2,LCK,PKD2,FAM119A,ATP6V0A2B,ATXN3,NSFL1C,TAF9 |
| enzyme binding | HIF1A,SUDS3,YES1,SLC12A3,PICK1,LAMB1,CD4,HDAC3,PRKCD,PHKG1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | DLX5,FOXA1,ZIC3,MZF1,ATF4,PITX2,GMEB1,EBF1,MEF2A,OTX2 |
| protein binding | CCDC123,RSPH3,ATP6V1C1,ZNF10,ARHGEF10,FGFRL1A,PLEKHN1,EVL,XRCC6,AIFM1 |
| steroid binding | CYP21A1,UGT1A1,PAQR5,HSD11B2,ESRRGA,HSD17B10,PAQR7A,PDIA2,ESR2B,NR3C2 |
Interacting Protein
PGR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PGR here. Most of them are supplied by our site. Hope this information will be useful for your research of PGR.
CUEDC2;STAT3;SP1;r_5020_promegestone;PRMT2;JDP2;SMARCD1
Resources
Research Area
Transcription Regulators in VSMCFertilization Molecules
Breast Cancer Biomarkers
Cancer Biomarkers in Clinical Practice
Related Services
Related Products
References
- Tosovic, A; Bondeson, AG; et al. T3 levels in relation to prognostic factors in breast cancer: a population-based prospective cohort study. BMC CANCER 14:-(2014).
- Yardley, DA; Tripathy, D; et al. Long-term survivor characteristics in HER2-positive metastatic breast cancer from registHER. BRITISH JOURNAL OF CANCER 110:2756-2764(2014).
