Recombinant Human PRMT1 Protein, GST-tagged

• Cat.No.: PRMT1-064H
• Product Overview: Active recombinant N-terminal GST-tagged full-length human PRMT1 protein (2-371) was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 2-371
• Description: This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5.
• Molecular Mass: 69.2 kDa
• Purity: ≥35% estimated by SDS-PAGE
• Unit Definition: One unit is the amount of enzyme required to transfer one methyl group to histone H4 per minute using 100 μmol histone H4 (1-21) peptide at 37 centigrade in a Methyltransferase Colorimetric Assay Kit.
• Stability: ≥ 6 months
• Storage: At -80 centigrade.

Gene Information

• Gene Name: PRMT1 protein arginine methyltransferase 1 [ Homo sapiens (human) ]
• Official Symbol: PRMT1
• Synonyms: PRMT1; protein arginine methyltransferase 1; ANM1; HCP1; IR1B4; HRMT1L2; protein arginine N-methyltransferase 1; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2; histone-arginine N-methyltransferase PRMT1; interferon receptor 1-bound protein 4; EC 2.1.1.319
• Gene ID: 3276
• mRNA Refseq: NM_198318
• Protein Refseq: NP_938074
• MIM: 602950
• UniProt ID: Q99873