Recombinant Human Protein Arginine Methyltransferase 1, His-MBP-tagged

• Cat.No.: PRMT1-1761H

Specification

• ProductOverview: Recombinant humanPRMT1, fused to His-MBP tag at N-terminus, was expressed in E. coli andpurified by using conventional chromatography techniques.
• Description: Protein arginineN-methyltransferase 1 (PRMT1) is a type I methyltransferase that transfers amethyl group from S-adenosylmethionine to guanidino nitrogens of arginineresidues to form monomethylarginine and asymmetric dimethylarginine.Functions of type I arginine methylation in proteins may include regulationof transcription, modulation of the affinity of nucleic acid-bindingproteins, regulation of interferon signaling pathways, and targeting ofnuclear proteins.
• Concentration: 1 mg/ml
• Source: Human
• Host: E.coli
• Form: Supplied as a liquid in40mM Tris, pH 8.0, containing 100mM NaCl, 4mM MgCl2, 2mM DTT, and 40%glycerol.
• Purity: > 90% by SDS -PAGE
• Sequence: 1-353 amino acids:MHHHHHHMKI EEGKLVIWIN GDKGYNGLAE VGKKFEKDTG IKVTVEHPDK LEEKFPQVAA TGDGPDIIFWAHDRFGGYAQ SGLLAEITPD KAFQDKLYPF TWDAVRYNGK LIAYPIAVEA LSLIYNKDLL PNPPKTWEEIPALDKELKAK GKSALMFNLQ EPYFTWPLIA ADGGYAFKYE NGKYDIKDVG VDNAGAKAGL TFLVDLIKNKHMNAD
• MolecularMass: 84 kDa (750 aa)
• Applications: SDS-PAGE
• Storage: Store at 4 deg C forshort term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg Cfor long term storage. Avoid repeated freeze/thaw cycles.
• OfficialSymbol: PRMT1
• Tag: His&Myc

Gene Information

• Gene Name: PRMT1protein arginine methyltransferase 1 [ Homo sapiens ]
• Synonyms: PRMT1; proteinarginine methyltransferase 1; ANM1; HCP1; IR1B4; HMT2; HRMT1L2; EC 2.1.1; EC2.1.1.77; EC 2.1.1.125; Interferon receptor 1-bound protein 4; proteinarginine N-methyltransferase 1; OTTHUMP00000236172; OTTHUMP00000236176;OTTHUMP00000236178; OTTHUMP00000236179; HMT1 hnRNP methyltransferase-like 2;interferon receptor 1-bound protein 4; Histone-arginine N-methyltransferasePRMT1; HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae); HMT1 (hnRNPmethyltransferase, S. cerevisiae)-like 2
• Gene ID: 3276
• mRNA Refseq: NM_001536
• Protein Refseq: NP_001527
• MIM: 602950
• UniProt ID: Q99873
• Chromosome Location: 19q13.3
• Pathway: AndrogenReceptor Signaling Pathway; Direct p53 effectors; Energy Metabolism;Tryptophan metabolism; mRNA processing
• Function: N-methyltransferaseactivity; histone methyltransferase activity; histone methyltransferaseactivity (H4-R3 specific); methyltransferase activity; protein binding;transferase activity