Recombinant Human Prefoldin Subunit 1, His-tagged

• Cat.No.: PFDN1-2855H
• Product Overview: Recombinant human PFDN1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. MW = 15.0kDa (130aa), confirmed by MALDI-TOF.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: PFDN1 is one of sixsubunits of prefoldin, a heterohexameric chaperone protein which assists in the correct folding of other proteins. This protein delivers nonnative target proteins, principally actins and tubulins, to the eukaryotic cytosolic chaperonin for facilitated folding. Defects in PFDN1 displayed phenotypes characteristic of defects in cytoskeletal function, including manifestations of ciliary dyskinesia, neuronal loss, and defects in B and T cell development and function.
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MTELQAKVID TQQKVKLADI QIEQLNRTKK HAHLTDTEIM TLVDETNMYE GVGRMFILQS KEAIHSQLLE KQKIAEEKIK ELEQKKSYLE RSVKEAEDNI REMLMARRAQ
• Purity: > 90% by SDS – PAGE.
• Form: Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 20% Glycerol.
• Concentration: 0.5 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: PFDN1 prefoldin subunit 1 [ Homo sapiens ]
• Synonyms: PFDN1; prefoldin subunit 1; PDF; PFD1; prefoldin subunit 1; prefoldin 1
• Gene ID: 5201
• mRNA Refseq: NM_002622
• Protein Refseq: NP_002613
• MIM: 604897
• UniProt ID: O60925
• Chromosome Location: 5q31
• Function: protein binding; sequence-specific DNA binding transcription factor activity; unfolded protein binding