PFDN1
-
Official Full Name
prefoldin subunit 1 -
Overview
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. -
Synonyms
PFDN1;prefoldin subunit 1;prefoldin 1;PFD1;PDF
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- GST
- T7
- His&T7
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PFDN1 involved in several pathways and played different roles in them. We selected most pathways PFDN1 participated on our site, such as Chaperonin-mediated protein folding,Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFDN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chaperonin-mediated protein folding | CCT2,FBXW5,CCT4,TUBA3D,KIFC3,VBP1,CCT3,FBXL5,PFDN2,FBXW4 |
| Metabolism of proteins | SLC35A1,TRAPPC10,ADAMTSL4,CNIH3,CPB1,TRAPPC1,TRAPPC2L,IGFBP5A,EIF5A2,SFTPBB |
| Protein folding | PFDN4,FBXW5,FBXL5,TBCA,FBXW2,VBP1,KIFC3,TBCD,PFDN6,PFDN2 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | CCT4,CCT5,PFDN6,PFDN4,TUBA3D,CCT3,TUBA1B,PFDN5,CCT8,TCP1 |
| Prefoldin mediated transfer of substrate to CCT/TriC | PFDN5,PFDN6,CCT6A,CCT7,PFDN4,VBP1,PFDN2 |
Protein Function
PFDN1 has several biochemical functions, for example, protein binding involved in protein folding,transcription factor activity, sequence-specific DNA binding,unfolded protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PFDN1 itself. We selected most functions PFDN1 had, and list some proteins which have the same functions with PFDN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding involved in protein folding | HSPA1A,CD74,RIC3,HSPA1B,PDCL3,CLGN,CALR3,DNAJB8,CALR,PFDN2 |
| unfolded protein binding | HSP90AA1.2,CCT6B,CCT2,LMAN1,CCT5,CDC37L1,UGGT1,CALR,DNAJB8,CRYAA |
| transcription factor activity, sequence-specific DNA binding | HIF1AL,MEOX1,AHRRB,ZNF726,ZNF207,NR2F6A,GTF2H4,FLI1A,DMRT2B,SALL4 |
Interacting Protein
PFDN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFDN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PFDN1.
IMMT;GIT1;PRPF4;Tubb4b;IKBKE;RNPS1;MAP3K3;WRAP73;HIP1;NDC80;PLXNB2;ASNA1;SEC31A;EOMES;ALB;RPLP1;NR2F1;CHGA
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