Recombinant Human PPM1G, His-tagged
| Cat.No. : | PPM1G-31050TH |
| Product Overview : | Recombinant fragment, corresponding to amino acids 25-420 of Human PPM1G fused to His-tag at N-terminus, 27 kDa. |
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| Description : | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. |
| Conjugation : | HIS |
| Source : | E. coli |
| Tissue specificity : | Widely expressed. Most abundant in testis, skeletal muscle, and heart. |
| Form : | Liquid |
| Purity : | >95% by SDS-PAGE |
| Storage buffer : | Preservative: NoneConstituents: 20% Glycerol, 25mM Tris, 2mM Beta mercaptoethanol, 1mM DTT, 1mM EDTA, pH 7.5 |
| Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
| Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MEGKEEPGSD SGTTAVVALI RGKQLIVANA GDSRCVVSEA GKALDMSYDH KPEDEVELAR IKNAGGKVTM DGRVNGGLNL SRAIGDHFYK RNKNLPPEEQ MISALPDIKV LTLTDDHEFM VIACDGIWNV MSSQEVVDFI QSKISQRDEN GELRLLSSIV EELLDQCLAP DTSGDGTGCD NMTCIIICFK PRNTAELQPE SGKRKLEEVL STEGAEENGN SDKKKKAKRD |
| Sequence Similarities : | Belongs to the PP2C family. |
| Protein length : | 25-420 a.a. |
| Gene Name | PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G [ Homo sapiens ] |
| Official Symbol | PPM1G |
| Synonyms | PPM1G; protein phosphatase, Mg2+/Mn2+ dependent, 1G; protein phosphatase 1G (formerly 2C), magnesium dependent, gamma isoform; protein phosphatase 1G; PP2C; gamma; PP2CG; PP2Cgamma; protein phosphatase 2C; gamma isoform; |
| Gene ID | 5496 |
| mRNA Refseq | NM_177983 |
| Protein Refseq | NP_817092 |
| MIM | 605119 |
| Uniprot ID | O15355 |
| Chromosome Location | 2p23.3 |
| Pathway | mRNA processing, organism-specific biosystem; |
| Function | hydrolase activity; metal ion binding; protein serine/threonine phosphatase activity; |
Not For Human Consumption!
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