PPM1G
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Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent, 1G -
Overview
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. -
Synonyms
PPM1G;protein phosphatase, Mg2+/Mn2+ dependent, 1G;protein phosphatase 1G (formerly 2C), magnesium dependent, gamma isoform;protein phosphatase 1G;PP2C;gamma;PP2CG;PP2Cgamma;protein phosphatase 2C;gamma isoform;"PP2C;MGC1675;MGC2870;OTTHUMP00000123426;PP2C gamma;PP2C-gamma;PPM1G_HUMAN;PPP2CG;Protein phosphatase 1C;Protein phosphatase 2 catalytic subunit gamma isoform;Protein phosphatase 2C gamma isoform;Protein phosphatase 2C isoform gamma;Protein phosphatase magnesium dependent 1 gamma;Protein phosphatase magnesium-dependent 1 gamma;PP2C, gamma;protein phosphatase 2, catalytic subunit, gam
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- Cynomolgus
- E.coli
- Mammalian Cell
- Human
- HEK293
- Insect cell
- HEK293T
- Mammalian cells
- His
- Non
- GST
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PPM1G involved in several pathways and played different roles in them. We selected most pathways PPM1G participated on our site, such as mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPM1G were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA processing | SF3B2,RBM5,SPOP,HNRNPL,CLK3,SNRPN,SFPQ,HNRNPA2B1,PSKH1,RBM12B1 |
Protein Function
PPM1G has several biochemical functions, for example, metal ion binding,protein binding,protein serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPM1G itself. We selected most functions PPM1G had, and list some proteins which have the same functions with PPM1G. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine phosphatase activity | DUSP23B,PPP2R2A,PTEN,TAB1,DUSP23A,DUSP23,PPEF2,PPM1BB,EPM2A,CTDNEP1 |
| metal ion binding | ITGAX,DAK,KLK1B3,ARMC1L,ZDHHC16B,TUT1,FCN1,RHOT1A,ZNF396,ATP1A3A |
| protein binding | TTK,DMBT1,SRSF11,PSMD11,SRF,UBL7,MPHOSPH6,BAG2,CCDC116,VEGFAB |
Interacting Protein
PPM1G has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPM1G here. Most of them are supplied by our site. Hope this information will be useful for your research of PPM1G.
tat;TERF1;USP49;BAP1;USP7;USP36;TRAF6;LRPAP1;RPS6KA1;TERF2;acpA;FBXO38;TERF2IP;YEATS4;TP53;TFEB;MTNR1B
Resources
Research Area
Phosphatases and RegulatorsAdherens Junction Proteins in Endothelial Cells
Adherens Junction Proteins in VSMC
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References
- Husedzinovic, A; Neumann, B; et al. The catalytically inactive tyrosine phosphatase HD-PTP/PTPN23 is a novel regulator of SMN complex localization. MOLECULAR BIOLOGY OF THE CELL 26:161-171(2015).
- Chaudhary, N; Maddika, S; et al. WWP2-WWP1 Ubiquitin Ligase Complex Coordinated by PPM1G Maintains the Balance between Cellular p73 and Delta Np73 Levels. MOLECULAR AND CELLULAR BIOLOGY 34:3754-3764(2014).
